1980-2000

Preliminary Studies: Animal and early human research on GIK

1993

Development and testing of aids for diagnosing a heart attack
Acute Cardiac Ischemia-Time Insensitive Predictive Instrument (ACI-TIPI) Trial
Annals of Internal Medicine. December 1, 1998; 129:11, 845-855.

1997

Development and testing of an aid for emergency treatment for a heart attack
Thrombolytic Predictive Instrument (TPI) Trial
Annals of Internal Medicine July 16, 2002; Volume 137: 2,87-95.

2002

IMMEDIATE Pilot Trial
3 month feasibility study of the administration of GIK in the prehospital setting. Conducted at Emerson Hospital and Emerson Hospital EMS; 115 patients screened, 29 enrolled.

2004

National Institutes of Health’s (NIH) National Heart, Lung, Blood Institute (NHLBI) approves funding of Nationwide IMMEDIATE Trial

2006

Massachusetts Dept. of Public Health Office of Emergency Medical Services approves waiver for special projects.

2006

IMMEDIATE Trial enrollment began across the US.

2008

IMMEDIATE Trial site expansion.

2009

Enrollment into the Biological Mechanism Cohort began in April
Enrollment into the Genetic Ancillary Study began in June

2010

The 700^th patient was enrolled in the IMMEDIATE Trial in August